Chemistry:Azumolene
From HandWiki
Short description: Chemical compound
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| Formula | C13H9BrN4O3 |
| Molar mass | 349.144 g·mol−1 |
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Azumolene is an experimental drug which is a derivative of dantrolene. In animal studies, azumolene showed similar efficacy to dantrolene at controlling symptoms of malignant hyperthermia but with better water solubility and lower toxicity, albeit with lower potency.[1][2][3]
References
- ↑ "Effects of azumolene on normal and malignant hyperthermia-susceptible skeletal muscle". Basic & Clinical Pharmacology & Toxicology 102 (3): 308–16. March 2008. doi:10.1111/j.1742-7843.2007.00156.x. PMID 18047479.
- ↑ "Intravenous administration of azumolene to reverse malignant hyperthermia in swine". Journal of Veterinary Internal Medicine 24 (5): 1224–8. 2010. doi:10.1111/j.1939-1676.2010.0556.x. PMID 20584138.
- ↑ "N-Acylhydrazones as drugs". Bioorganic & Medicinal Chemistry Letters 28 (17): 2797–2806. September 2018. doi:10.1016/j.bmcl.2018.07.015. PMID 30006065.
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