Chemistry:Anaritide

Anaritide
	Tertiary structure of Anaritide
Identifiers
	IUPAC name L-arginyl-L-seryl-L-seryl-L-cysteinyl-L-phenylalanyl-glycyl-glycyl-L-arginyl-L-methionyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-glycyl-L-alanyl-L-glutaminyl-L-seryl-glycyl-L-leucyl-glycyl-L-cysteinyl-L-asparagyl-L-seryl-L-phenylalanyl-L-arginyl-L-tyrosine;
CAS Number	95896-08-5 ;
PubChem CID	16132382;
ChemSpider	17294213;
UNII	1M00R25BPL;
Chemical and physical data
Formula	C112H177N39O35S3
Molar mass	2726.07 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC(C)C(C(=O)NCC(=O)NC(C)C(=O)NC(CCC(=O)N)C(=O)NC(CO)C(=O)NCC(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CS)C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(=O)O)NC(=O)C(CCSC)NC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)C(CC3=CC=CC=C3)NC(=O)C(CS)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CCCNC(=N)N)N;
	InChI InChI=1S/C112H177N39O35S3/c1-7-56(4)88(151-98(175)65(25-17-36-127-112(122)123)139-101(178)72(43-87(164)165)144-97(174)67(32-37-189-6)140-94(171)63(23-15-34-125-110(118)119)134-84(161)45-128-82(159)44-129-92(169)69(39-58-18-10-8-11-19-58)141-106(183)79(54-188)150-104(181)77(52-155)149-103(180)75(50-153)146-90(167)62(113)22-14-33-124-109(116)117)107(184)132-46-83(160)133-57(5)89(166)137-66(30-31-80(114)157)96(173)147-74(49-152)93(170)131-47-85(162)135-68(38-55(2)3)91(168)130-48-86(163)136-78(53-187)105(182)143-71(42-81(115)158)100(177)148-76(51-154)102(179)142-70(40-59-20-12-9-13-21-59)99(176)138-64(24-16-35-126-111(120)121)95(172)145-73(108(185)186)41-60-26-28-61(156)29-27-60/h8-13,18-21,26-29,55-57,62-79,88,152-156,187-188H,7,14-17,22-25,30-54,113H2,1-6H3,(H2,114,157)(H2,115,158)(H,128,159)(H,129,169)(H,130,168)(H,131,170)(H,132,184)(H,133,160)(H,134,161)(H,135,162)(H,136,163)(H,137,166)(H,138,176)(H,139,178)(H,140,171)(H,141,183)(H,142,179)(H,143,182)(H,144,174)(H,145,172)(H,146,167)(H,147,173)(H,148,177)(H,149,180)(H,150,181)(H,151,175)(H,164,165)(H,185,186)(H4,116,117,124)(H4,118,119,125)(H4,120,121,126)(H4,122,123,127)/t56-,57-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,88-/m0/s1; Key:PBSXKCQOTWYLMQ-LWECRCKRSA-N;

Short description: Synthetic Peptide

Anaritide (also known as human atrial natriuretic peptide [102-126])^[1] is a synthetic analogue of atrial natriuretic peptide^[2] (ANP).

Structure

Anartidine has the following primary structure:^[3]

RSSCFGGRMDRIGAQSGLGCNSFRY

or

H-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH

This structure is identical to residues 102-126 of human preproANP.^[1]^[4] In comparison, active human ANP comprises resides 99-126 of human preproANP.^[5]

Medical uses

Anaritide has been investigated as a potential therapy for acute tubular necrosis but was shown not to improve the dialysis-free survival of these patients.^[2] It also appears to exacerbate proteinuria and natriuresis in patients with nephrotic syndrome.^[6]

References

↑ ^1.0 ^1.1 "Bronchoprotective and bronchodilator activity of anaritide (human atrial natriuretic factor [102-126]) infusion in the anesthetized guinea pig". Pulmonary Pharmacology 1 (3): 119–123. 1988-07-22. doi:10.1016/S0952-0600(88)80009-7. PMID 2980981.
↑ ^2.0 ^2.1 "Anaritide in acute tubular necrosis. Auriculin Anaritide Acute Renal Failure Study Group". The New England Journal of Medicine 336 (12): 828–834. March 1997. doi:10.1056/NEJM199703203361203. PMID 9062091.
↑ "Splenic artery aneurysm of the anomalous splenomesenteric trunk: successful treatment by transcatheter embolization using detachable coils". CardioVascular and Interventional Radiology 29 (3): 432–434. 2006. doi:10.1007/s00270-005-0036-x. PMID 16132382.
↑ "Amino acid sequence of atrial natriuretic peptides in human coronary sinus plasma". Biochemical and Biophysical Research Communications 146 (2): 832–839. July 1987. doi:10.1016/0006-291X(87)90606-1. PMID 2956952.
↑ "Atrial natriuretic factor and related peptide hormones". Annual Review of Biochemistry 60: 229–255. 1991. doi:10.1146/annurev.bi.60.070191.001305. PMID 1652921.
↑ "Effect of synthetic human atrial natriuretic peptide (102-126) in nephrotic syndrome". Kidney International 34 (5): 717–724. November 1988. doi:10.1038/ki.1988.238. PMID 2974095.

0.00

(0 votes)

Original source: https://en.wikipedia.org/wiki/Anaritide. Read more

[reference_1-1] 1.0 ^1.1 "Bronchoprotective and bronchodilator activity of anaritide (human atrial natriuretic factor [102-126]) infusion in the anesthetized guinea pig". Pulmonary Pharmacology 1 (3): 119–123. 1988-07-22. doi:10.1016/S0952-0600(88)80009-7. PMID 2980981.

[reference_2-2] 2.0 ^2.1 "Anaritide in acute tubular necrosis. Auriculin Anaritide Acute Renal Failure Study Group". The New England Journal of Medicine 336 (12): 828–834. March 1997. doi:10.1056/NEJM199703203361203. PMID 9062091.

[pubmed-3] "Splenic artery aneurysm of the anomalous splenomesenteric trunk: successful treatment by transcatheter embolization using detachable coils". CardioVascular and Interventional Radiology 29 (3): 432–434. 2006. doi:10.1007/s00270-005-0036-x. PMID 16132382.

[4] "Amino acid sequence of atrial natriuretic peptides in human coronary sinus plasma". Biochemical and Biophysical Research Communications 146 (2): 832–839. July 1987. doi:10.1016/0006-291X(87)90606-1. PMID 2956952.

[5] "Atrial natriuretic factor and related peptide hormones". Annual Review of Biochemistry 60: 229–255. 1991. doi:10.1146/annurev.bi.60.070191.001305. PMID 1652921.

[6] "Effect of synthetic human atrial natriuretic peptide (102-126) in nephrotic syndrome". Kidney International 34 (5): 717–724. November 1988. doi:10.1038/ki.1988.238. PMID 2974095.

[1]

[2]

[3]

[4]

[5]

[6]

Anonymous

Search

Chemistry:Anaritide

Namespaces

More

Page actions

Structure

Medical uses

References

Navigation

Navigation

Help

Translate

Wiki tools

Wiki tools

Identifiers
Tertiary structure of Anaritide
IUPAC name L-arginyl-L-seryl-L-seryl-L-cysteinyl-L-phenylalanyl-glycyl-glycyl-L-arginyl-L-methionyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-glycyl-L-alanyl-L-glutaminyl-L-seryl-glycyl-L-leucyl-glycyl-L-cysteinyl-L-asparagyl-L-seryl-L-phenylalanyl-L-arginyl-L-tyrosine
CAS Number	95896-08-5^Y
PubChem CID	16132382
ChemSpider	17294213
UNII	1M00R25BPL
Chemical and physical data
Formula	C₁₁₂H₁₇₇N₃₉O₃₅S₃
Molar mass	2726.07 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCC(C)C(C(=O)NCC(=O)NC(C)C(=O)NC(CCC(=O)N)C(=O)NC(CO)C(=O)NCC(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CS)C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(=O)O)NC(=O)C(CCSC)NC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)C(CC3=CC=CC=C3)NC(=O)C(CS)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CCCNC(=N)N)N
InChI InChI=1S/C112H177N39O35S3/c1-7-56(4)88(151-98(175)65(25-17-36-127-112(122)123)139-101(178)72(43-87(164)165)144-97(174)67(32-37-189-6)140-94(171)63(23-15-34-125-110(118)119)134-84(161)45-128-82(159)44-129-92(169)69(39-58-18-10-8-11-19-58)141-106(183)79(54-188)150-104(181)77(52-155)149-103(180)75(50-153)146-90(167)62(113)22-14-33-124-109(116)117)107(184)132-46-83(160)133-57(5)89(166)137-66(30-31-80(114)157)96(173)147-74(49-152)93(170)131-47-85(162)135-68(38-55(2)3)91(168)130-48-86(163)136-78(53-187)105(182)143-71(42-81(115)158)100(177)148-76(51-154)102(179)142-70(40-59-20-12-9-13-21-59)99(176)138-64(24-16-35-126-111(120)121)95(172)145-73(108(185)186)41-60-26-28-61(156)29-27-60/h8-13,18-21,26-29,55-57,62-79,88,152-156,187-188H,7,14-17,22-25,30-54,113H2,1-6H3,(H2,114,157)(H2,115,158)(H,128,159)(H,129,169)(H,130,168)(H,131,170)(H,132,184)(H,133,160)(H,134,161)(H,135,162)(H,136,163)(H,137,166)(H,138,176)(H,139,178)(H,140,171)(H,141,183)(H,142,179)(H,143,182)(H,144,174)(H,145,172)(H,146,167)(H,147,173)(H,148,177)(H,149,180)(H,150,181)(H,151,175)(H,164,165)(H,185,186)(H4,116,117,124)(H4,118,119,125)(H4,120,121,126)(H4,122,123,127)/t56-,57-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,88-/m0/s1 Key:PBSXKCQOTWYLMQ-LWECRCKRSA-N

Anonymous

Search

Chemistry:Anaritide

Structure

Medical uses

References

Navigation

Wiki tools

Page tools

Other projects

Categories