Chemistry:Altoqualine

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Altoqualine
Altoqualine.svg
Names
Preferred IUPAC name
(3S)-7-Amino-4,5,6-triethoxy-3-[(1R)-6,7,8-trimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]-2-benzofuran-1(3H)-one
Other names
458 L
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
UNII
Properties
C27H36N2O8
Molar mass 516.591 g·mol−1
Melting point 144 °C (291 °F; 417 K)[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Tracking categories (test):

Altoqualine is an isoquinoline once studied for its potential use as an antihistamine and antiallergic,[1][2][3] but it was never a marketed drug. It is an inhibitor of histidine decarboxylase.[2]

References

  1. 1.0 1.1 C.R. Ganellin; David J. Triggle (Nov 21, 1996). Dictionary of Pharmacological Agents. 1-2. CRC Press. p. 58. 
  2. 2.0 2.1 "Pharmacological approach of a new isoquinoline derivative (458 L)". Agents and Actions 11 (1–2): 41–43. 1981. doi:10.1007/BF01991453. PMID 7195643. 
  3. "Pharmacokinetic study of a new benzyl-1 isoquinoline derivative (458 L) after oral administration in men". Thérapie 45 (1): 7–11. 1990. PMID 1971461.