Chemistry:Aigialomycin D
From HandWiki
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| IUPAC name
(4S,6E,8R,9S,12E)-8,9,16,18-Tetrahydroxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaen-2-one
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| Identifiers | |
3D model (JSmol)
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| ChEMBL | |
PubChem CID
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| Properties | |
| C18H22O6 | |
| Molar mass | 334.368 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Aigialomycin D is a macrolide antibiotic which is produced by the fungi Aigialus parvus.[1] Aigialomycin D is a resorcylic acid lactone and has the molecular formula C18H22O6.[2] Preliminary studies found that aigialomycin D is a protein kinase inhibitor[3] with anti-tumor activity. Aigialomycin D has antimalarial activity.[4]
References
- ↑ Blunt, John W.; Munro, Murray H. G. (19 September 2007) (in en). Dictionary of Marine Natural Products with CD-ROM. CRC Press. p. 32. ISBN 978-0-8493-8217-8.
- ↑ Xu, Jin; Chen, Anqi; Go, Mei-Lin; Nacro, Kassoum; Liu, Boping; Chai, Christina L. L. (8 September 2011). "Exploring Aigialomycin D and Its Analogues as Protein Kinase Inhibitors for Cancer Targets". ACS Medicinal Chemistry Letters 2 (9): 662–666. doi:10.1021/ml200067t. PMID 24900361.
- ↑ (in en) Advances in Phosphotransferases (Alcohol Group Acceptor) Research and Application: 2012 Edition. ScholarlyEditions. 26 December 2012. p. 76. ISBN 978-1-4649-9201-8.
- ↑ Tiwari, Vinod K. (31 July 2020) (in en). Carbohydrates in Drug Discovery and Development: Synthesis and Application. Elsevier. p. 508. ISBN 978-0-12-816676-5.
Further reading
- Geng, Xudong; Danishefsky, Samuel J. (1 February 2004). "Total Synthesis of Aigialomycin D". Organic Letters 6 (3): 413–416. doi:10.1021/ol036258m. PMID 14748606.
- (in en) Studies in Natural Products Chemistry. Elsevier. 20 January 2015. p. 386. ISBN 978-0-444-63470-2.
- Taber, Douglass (23 September 2011) (in en). Organic Synthesis: State of the Art 2007 - 2009. Oxford University Press. p. 101. ISBN 978-0-19-020877-6.
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