Chemistry:ADX71743
From HandWiki
Short description: Chemical compound
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| Formula | C17H19NO2 |
| Molar mass | 269.344 g·mol−1 |
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ADX71743 is a drug which acts as a potent and selective negative allosteric modulator of the metabotropic glutamate receptor 7.[1] Few selective ligands are available for this receptor, and so ADX71743 has played an important role into scientific research into the role of this receptor in various processes such as memory formation, nociception, absence seizures and psychosis.[2][3][4][5]
References
- ↑ "ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization". The Journal of Pharmacology and Experimental Therapeutics 344 (3): 624–636. March 2013. doi:10.1124/jpet.112.200915. PMID 23257312.
- ↑ "Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SC-CA1 Synapses in the Hippocampus". The Journal of Neuroscience 35 (19): 7600–7615. May 2015. doi:10.1523/JNEUROSCI.4543-14.2015. PMID 25972184.
- ↑ "Negative allosteric modulation of the mGlu7 receptor reduces visceral hypersensitivity in a stress-sensitive rat strain". Neurobiology of Stress 2: 28–33. 2015. doi:10.1016/j.ynstr.2015.04.001. PMID 26844237.
- ↑ "Phasic and Tonic mGlu7 Receptor Activity Modulates the Thalamocortical Network". Frontiers in Neural Circuits 10: 31. 2016. doi:10.3389/fncir.2016.00031. PMID 27199672.
- ↑ "Negative Allosteric Modulators of mGlu7 Receptor as Putative Antipsychotic Drugs". Frontiers in Molecular Neuroscience 11: 316. 2018. doi:10.3389/fnmol.2018.00316. PMID 30294258.
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