Chemistry:β-Ketoisocaproic acid

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β-Ketoisocaproic acid
Skeletal formula of beta-ketoisocaproic acid
Names
Preferred IUPAC name
4-Methyl-3-oxopentanoic acid
Other names
4-Methyl-3-oxopentanoic acid
4-Methyl-3-oxovaleric acid
Isobutanoylacetic acid
Isobutyrylacetic acid
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
KEGG
MeSH Beta-ketoisocaproic+acid
UNII
Properties
C6H10O3
Molar mass 130.143 g·mol−1
Density 1.1 g cm−3 (at 20 °C)
Boiling point 236 °C (457 °F; 509 K) ±23 at 760 mmHg
log P 0.36
Hazards
GHS pictograms GHS05: Corrosive
GHS Signal word Danger
H314
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Tracking categories (test):

β-Ketoisocaproic acid, also known as 4-methyl-3-oxopentanoic acid, is an intermediate in the metabolism of leucine.[1][2] Its metabolic precursor and metabolic product in the leucine metabolic pathway are β-leucine and β-ketoisocaproyl-CoA, respectively.[1]

References

  1. 1.0 1.1 Nutrient Metabolism: Structures, Functions, and Genes (2nd ed.). Academic Press. May 2015. pp. 385–388, Figure 8.57. ISBN 978-0-12-387784-0. https://books.google.com/books?id=aTQTAAAAQBAJ. Retrieved 6 June 2016. "Energy fuel: Eventually, most Leu is broken down, providing about 6.0kcal/g. About 60% of ingested Leu is oxidized within a few hours ... Ketogenesis: A significant proportion (40% of an ingested dose) is converted into acetyl-CoA and thereby contributes to the synthesis of ketones, steroids, fatty acids, and other compounds ...
    "
     
  2. "Leucine metabolism". Technische Universität Braunschweig. http://www.brenda-enzymes.org/pathways/Maps/pathways/leucine_metabolism.svg.