Biology:Vinculin family

From HandWiki
Short description: Protein family
Vinculin family
Identifiers
SymbolVinculin
PfamPF01044
InterProIPR006077
PROSITEPDOC00568
SCOP21dow / SCOPe / SUPFAM

Vinculin is a eukaryotic protein that seems to be involved in the attachment of the actin-based microfilaments to the plasma membrane. Vinculin is located at the cytoplasmic side of focal contacts or adhesion plaques.[1] In addition to actin, vinculin interacts with other structural proteins such as talin and alpha-actinins.

Vinculin is a large protein of 116 kDa (about a 1000 residues). Structurally the protein consists of an acidic N-terminal domain of about 90 kDa separated from a basic C-terminal domain of about 25 kDa by a proline-rich region of about 50 residues. The central part of the N-terminal domain consists of a variable number (3 in vertebrates, 2 in Caenorhabditis elegans) of repeats of a 110 amino acids domain.

Alpha-catenins are evolutionary related to vinculin.[2] Catenins are proteins that associate with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Three different types of catenins seem to exist: alpha, beta, and gamma. Alpha-catenins are proteins of about 100 kDa which are evolutionary related to vinculin. In terms of their structure the most significant differences are the absence, in alpha-catenin, of the repeated domain and of the proline-rich segment.

Subfamilies

Human proteins containing this domain

CTNNA1; CTNNA2; CTNNA3; CTNNAL1; VCL;

References

  1. Otto JJ (1990). "Vinculin". Cell Motil. Cytoskeleton 16 (1): 1–6. doi:10.1002/cm.970160102. PMID 2112986. 
  2. "The uvomorulin-anchorage protein alpha catenin is a vinculin homologue". Proc. Natl. Acad. Sci. U.S.A. 88 (20): 9156–9160. 1991. doi:10.1073/pnas.88.20.9156. PMID 1924379. Bibcode1991PNAS...88.9156H. 
This article incorporates text from the public domain Pfam and InterPro: IPR006077