Biology:Tyrosine phenol-lyase

From HandWiki
tyrosine phenol-lyase
Identifiers
EC number4.1.99.2
CAS number9059-31-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

The enzyme tyrosine phenol-lyase (EC 4.1.99.2) catalyzes the chemical reaction

L-tyrosine + H2O [math]\displaystyle{ \rightleftharpoons }[/math] phenol + pyruvate + NH3

This enzyme belongs to the family of lyases, specifically in the "catch-all" class of carbon-carbon lyases. The systematic name of this enzyme class is L-tyrosine phenol-lyase (deaminating; pyruvate-forming). Other names in common use include beta-tyrosinase, and L-tyrosine phenol-lyase (deaminating). This enzyme participates in tyrosine metabolism and nitrogen metabolism. It employs one cofactor, pyridoxal phosphate.

Structural studies

As of late 2007, five structures have been solved for this class of enzyme, with PDB accession codes 1C7G, 1TPL, 2EZ1, 2EZ2, and 2TPL.

References

  • "Tyrosine phenol lyase. I. Purification, crystallization, and properties". J. Biol. Chem. 245 (7): 1767–72. 1970. PMID 4908868. 
  • "Tyrosine phenol lyase. II. Cofactor requirements". J. Biol. Chem. 245 (7): 1773–7. 1970. PMID 4908869.