Biology:TOMM34
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Mitochondrial import receptor subunit TOM34 is a protein that in humans is encoded by the TOMM34 gene.[1][2]
The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats.[2]
References
- ↑ "hTom34: a novel translocase for the import of proteins into human mitochondria". DNA Cell Biol 16 (9): 1067–74. Oct 1997. doi:10.1089/dna.1997.16.1067. PMID 9324309.
- ↑ 2.0 2.1 "Entrez Gene: TOMM34 translocase of outer mitochondrial membrane 34". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10953.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90". J. Biol. Chem. 273 (29): 18007–10. 1998. doi:10.1074/jbc.273.29.18007. PMID 9660753.
- "Characterization of the novel mitochondrial protein import component, Tom34, in mammalian cells". J. Biochem. 125 (4): 721–7. 1999. doi:10.1093/oxfordjournals.jbchem.a022342. PMID 10101285.
- "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics 76 (1–3): 45–57. 2001. doi:10.1006/geno.2001.6584. PMID 11549316.
- "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. 2002. doi:10.1038/414865a. PMID 11780052. Bibcode: 2001Natur.414..865D.
- "Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins". Arch. Biochem. Biophys. 400 (1): 97–104. 2002. doi:10.1006/abbi.2002.2777. PMID 11913975.
- "Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol". Arch. Biochem. Biophys. 400 (1): 105–10. 2002. doi:10.1006/abbi.2002.2778. PMID 11913976.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target". Int. J. Oncol. 29 (2): 381–6. 2006. doi:10.3892/ijo.29.2.381. PMID 16820880.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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