Biology:TNKS

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A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Tankyrase-1 is an enzyme that in humans is encoded by the TNKS gene.[1][2][3]

Description[4]

Tankyrase-1 is a poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity.[5]

Protein interactions

TNKS has been shown to interact with:


References

  1. 1.0 1.1 "Tankyrase, a poly(ADP-ribose) polymerase at human telomeres". Science 282 (5393): 1484–7. Dec 1998. doi:10.1126/science.282.5393.1484. PMID 9822378. 
  2. "Chromosomal mapping of the tankyrase gene in human and mouse". Genomics 57 (2): 320–1. May 1999. doi:10.1006/geno.1999.5771. PMID 10198177. 
  3. "Entrez Gene: TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8658. 
  4. https://www.uniprot.org/uniprot/O95271
  5. "The 26S proteasome: a molecular machine designed for controlled proteolysis". Annu. Rev. Biochem. 68: 1015–68. 1999. doi:10.1146/annurev.biochem.68.1.1015. PMID 10872471. 
  6. "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance". FEBS Lett. 554 (1–2): 10–6. Nov 2003. doi:10.1016/s0014-5793(03)01063-9. PMID 14596906. 
  7. "Tankyrase 1 interacts with Mcl-1 proteins and inhibits their regulation of apoptosis". J. Biol. Chem. 278 (7): 5195–204. Feb 2003. doi:10.1074/jbc.M201988200. PMID 12475993. 
  8. 8.0 8.1 "The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)". J. Biol. Chem. 277 (16): 14116–26. Apr 2002. doi:10.1074/jbc.M112266200. PMID 11854288. 
  9. 9.0 9.1 "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner". J. Biol. Chem. 277 (35): 31887–92. Aug 2002. doi:10.1074/jbc.M203916200. PMID 12080061. 
  10. "Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres". Mol. Cell. Biol. 22 (1): 332–42. Jan 2002. doi:10.1128/mcb.22.1.332-342.2002. PMID 11739745. 
  11. "Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase)". Biochem. J. 361 (Pt 3): 451–9. Feb 2002. doi:10.1042/0264-6021:3610451. PMID 11802774. 

Further reading