Biology:Sex-lethal
| IPR006546 | |
|---|---|
| Identifiers | |
| Symbol | Sxl |
| InterPro | IPR006546 |
Sex-lethal (Sxl) is a gene found in Dipteran insects, named for its mutation phenotype in Drosophila melanogaster (P19339).[1][2] It is most closely related to the ELAV/HUD subfamily of splicing factors.[3]
In fruit flies, this protein participates in alternative splicing of the transformer gene, deciding the sex of the fly.[4] It induces female-specific alternative splicing of the transformer (tra) pre-mRNA by binding to the tra uridine-rich polypyrimidine tract at the non-sex-specific 3' splice site during the sex-determination process. SXL binds also to its own pre-mRNA and promotes female-specific alternative splicing.[5][6] SXL contains an N-terminal Gly/Asn-rich domain that may be responsible for the protein-protein interaction, and tandem RNA recognition motifs (RRMs) that show high preference to bind single-stranded, uridine-rich target RNA transcripts.[7]
References
- ↑ "The Sex-lethal gene of Drosophila: DNA alterations associated with sex-specific lethal mutations" (in English). Cell 43 (2 Pt 1): 521–9. December 1985. doi:10.1016/0092-8674(85)90181-3. PMID 3000609.
- ↑ "Sex-lethal, the master sex-determining gene in Drosophila, is not sex-specifically regulated in Musca domestica". Development 125 (8): 1487–94. April 1998. doi:10.1242/dev.125.8.1487. PMID 9502729. https://www.zora.uzh.ch/id/eprint/170/8/Meise_1998.pdf.
- ↑ "Structure, function and evolution of sex-determining systems in Dipteran insects". Development 127 (4): 667–77. February 2000. doi:10.1242/dev.127.4.667. PMID 10648226.
- ↑ "Sex-lethal, a Drosophila sex determination switch gene, exhibits sex-specific RNA splicing and sequence similarity to RNA binding proteins". Cell 55 (6): 1037–46. December 1988. doi:10.1016/0092-8674(88)90248-6. PMID 3144435.
- ↑ "Absence of interdomain contacts in the crystal structure of the RNA recognition motifs of Sex-lethal". Proceedings of the National Academy of Sciences of the United States of America 96 (9): 4892–7. April 1999. doi:10.1073/pnas.96.9.4892. PMID 10220389. Bibcode: 1999PNAS...96.4892C.
- ↑ "RNA binding protein sex-lethal (Sxl) and control of Drosophila sex determination and dosage compensation". Microbiology and Molecular Biology Reviews 67 (3): 343–59, table of contents. September 2003. doi:10.1128/mmbr.67.3.343-359.2003. PMID 12966139.
- ↑ "Activities of the Sex-lethal protein in RNA binding and protein:protein interactions". Nucleic Acids Research 26 (11): 2625–37. June 1998. doi:10.1093/nar/26.11.2625. PMID 9592147.
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