Biology:Sarcalumenin
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Sarcalumenin is a protein that in humans is encoded by the SRL gene.[1][2]
Sarcalumenin is a calcium-binding protein that can be found in the sarcoplasmic reticulum of striated muscle.[3] Sarcalumenin is partially responsible for calcium buffering in the lumen of the sarcoplasmic reticulum and helps out calcium pump proteins.[4] Additionally, sarcalumenin is necessary for keeping a normal sinus rhythm during both aerobic and anaerobic exercise activity.[3] Sarcalumenin is a calcium-binding glycoprotein composed of 473 acidic amino acids with a molecular weight of 160 KDa. Together along with other luminal calcium buffer proteins, sarcalumenin plays an important role in regulation of calcium uptake and release during excitation-contraction coupling (ECC) in muscle fibers.
References
- ↑ "Molecular cloning and expression of cDNA encoding a lumenal calcium binding glycoprotein from sarcoplasmic reticulum". Proceedings of the National Academy of Sciences of the United States of America 86 (16): 6047–51. August 1989. doi:10.1073/pnas.86.16.6047. PMID 2762314. Bibcode: 1989PNAS...86.6047L.
- ↑ "Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization". Genome Research 6 (1): 35–42. January 1996. doi:10.1101/gr.6.1.35. PMID 8681137.
- ↑ 3.0 3.1 "Sarcalumenin is essential for maintaining cardiac function during endurance exercise training". American Journal of Physiology. Heart and Circulatory Physiology 297 (2): H576-82. August 2009. doi:10.1152/ajpheart.00946.2008. PMID 19502553.
- ↑ "Impaired Ca2+ store functions in skeletal and cardiac muscle cells from sarcalumenin-deficient mice". The Journal of Biological Chemistry 280 (5): 3500–6. February 2005. doi:10.1074/jbc.M406618200. PMID 15569689.
External links
- sarcalumenin at the US National Library of Medicine Medical Subject Headings (MeSH)
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