Biology:STARD13
 Generic protein structure example |
StAR-related lipid transfer domain protein 13 (STARD13) also known as deleted in liver cancer 2 protein (DLC-2) is a protein that in humans is encoded by the STARD13 gene and a member of the DLC family of proteins.[1][2]
Function and structure
STARD13 serves as a Rho GTPase-activating protein (GAP), a type of protein that regulates members of the Rho family of GTPases.[3] It selectively activates RhoA and CDC42 and suppresses cell growth by inhibiting actin stress fiber assembly.[3]
The protein consists of an N-terminal sterile alpha motif (SAM) domain,[4] a serine-rich domain, a RhoGAP domain and at the C-terminus, a StAR-related lipid-transfer domain (START).
Tissue distribution and pathology
The protein was identified in part through its differential expression in cancers. A low level of STARD13 was observed in less differentiated hepatocellular carcinoma tissue with higher RhoA expression. A small patient study finds that the absence of STARD13 in hepatocellular carcinomas correlates with higher levels of RhoA and a poorer prognosis than patients with carcinomas that were STARD13-positive.[5]
References
- ↑ "Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13". Genomics 36 (1): 86–99. August 1996. doi:10.1006/geno.1996.0428. PMID 8812419.
- ↑ "Entrez Gene: STARD13 START domain containing 13". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=90627.
- ↑ 3.0 3.1 "Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma". The Journal of Biological Chemistry 278 (12): 10824–30. March 2003. doi:10.1074/jbc.M208310200. PMID 12531887.
- ↑ Li, Hongyan; Fung, King-Leung; Jin, Dong-Yan; Chung, Stephen S. M.; Ching, Yick-Pang; Ng, Irene Oi-lin; Sze, Kong-Hung; Ko, Ben C. B. et al. (2007-06-01). "Solution structures, dynamics, and lipid-binding of the sterile alpha-motif domain of the deleted in liver cancer 2". Proteins 67 (4): 1154–1166. doi:10.1002/prot.21361. ISSN 1097-0134. PMID 17380510.
- ↑ "Underexpression of deleted in liver cancer 2 (DLC2) is associated with overexpression of RhoA and poor prognosis in hepatocellular carcinoma". BMC Cancer 8: 205. 2008. doi:10.1186/1471-2407-8-205. PMID 18651974.
Further reading
- "Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma". The Journal of Biological Chemistry 278 (12): 10824–30. March 2003. doi:10.1074/jbc.M208310200. PMID 12531887.
- "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". The Biochemical Journal 377 (Pt 3): 597–605. February 2004. doi:10.1042/BJ20031251. PMID 14561217.
- "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins". Biochemical and Biophysical Research Communications 313 (3): 654–65. January 2004. doi:10.1016/j.bbrc.2003.12.001. PMID 14697242.
- "Functional proteomics mapping of a human signaling pathway". Genome Research 14 (7): 1324–32. July 2004. doi:10.1101/gr.2334104. PMID 15231748.
- "Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity". Proceedings of the National Academy of Sciences of the United States of America 102 (42): 15207–12. October 2005. doi:10.1073/pnas.0504501102. PMID 16217026. Bibcode: 2005PNAS..10215207L.
PDB gallery | |
|---|---|
|
 |  |
