Biology:S100A6

Short description: Human protein and coding gene

S100 calcium-binding protein A6 (S100A6) is a protein that in humans is encoded by the S100A6 gene.^[1]

Function

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.^[1]

Interactions

S100A6 has been shown to interact with S100B^[2]^[3] and SUGT1.^[4]

Pathology

S100A6 to be reported as possible diagnostic marker of papillary thyroid carcinoma.^[5]

References

↑ ^1.0 ^1.1 "Entrez Gene: S100A6 S100 calcium binding protein A6". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6277.
↑ "S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo". J. Biol. Chem. 275 (45): 35302–10. November 2000. doi:10.1074/jbc.M003943200. PMID 10913138.
↑ "Demonstration of heterodimer formation between S100B and S100A6 in the yeast two-hybrid system and human melanoma". Exp. Cell Res. 246 (2): 501–9. February 1999. doi:10.1006/excr.1998.4314. PMID 9925766.
↑ "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins". J. Biol. Chem. 278 (29): 26923–8. July 2003. doi:10.1074/jbc.M211518200. PMID 12746458.
↑ "Proteomic study of thyroid tumors reveals frequent up-regulation of the Ca2+ -binding protein S100A6 in papillary thyroid carcinoma". Thyroid 20 (10): 1067–76. October 2010. doi:10.1089/thy.2009.0400. PMID 20629554.

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"Molecular cloning of the cDNA for a growth factor-inducible gene with strong homology to S-100, a calcium-binding protein". J. Biol. Chem. 261 (27): 12628–32. 1986. doi:10.1016/S0021-9258(18)67137-6. PMID 3755724.
"Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics 25 (3): 638–43. 1995. doi:10.1016/0888-7543(95)80005-7. PMID 7759097.
"Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E". Proc. Natl. Acad. Sci. U.S.A. 90 (14): 6547–51. 1993. doi:10.1073/pnas.90.14.6547. PMID 8341667. Bibcode: 1993PNAS...90.6547E.
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"Demonstration of heterodimer formation between S100B and S100A6 in the yeast two-hybrid system and human melanoma". Exp. Cell Res. 246 (2): 501–9. 1999. doi:10.1006/excr.1998.4314. PMID 9925766.
"Characterization of the calcyclin (S100A6) binding site of annexin XI-A by site-directed mutagenesis". FEBS Lett. 444 (1): 11–4. 1999. doi:10.1016/S0014-5793(99)00014-9. PMID 10037139.
"S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo". J. Biol. Chem. 275 (45): 35302–10. 2000. doi:10.1074/jbc.M003943200. PMID 10913138.
"Construction of cDNA representational difference analysis based on two cDNA libraries and identification of garlic inducible expression genes in human gastric cancer cells". World J. Gastroenterol. 8 (2): 208–12. 2002. doi:10.3748/wjg.v8.i2.208. PMID 11925593.
"Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution". Structure 10 (4): 557–67. 2002. doi:10.1016/S0969-2126(02)00740-2. PMID 11937060.
"CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family". J. Biol. Chem. 277 (32): 28848–52. 2002. doi:10.1074/jbc.M203602200. PMID 12042313.