Biology:PRB1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Basic salivary proline-rich protein 1 is a protein that in humans is encoded by the PRB1 gene.

The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Further reading

• "Molecular Genetics of Human Salivary Proteins and Their Polymorphisms". Advances in Human Genetics 1. 17. 1988. 141–99. doi:10.1007/978-1-4613-0987-1_5. ISBN 978-1-4612-8279-2. 
• Bennick A (1982). "Salivary proline-rich proteins". Mol. Cell. Biochem. 45 (2): 83–99. doi:10.1007/BF00223503. PMID 6810092. 
• "New Genetic marker in human parotid saliva (pm)". Science 197 (4301): 378–9. 1977. doi:10.1126/science.877561. PMID 877561. Bibcode: 1977Sci...197..378I. 
• "A 13-amino acid n-terminal domain of a basic proline-rich protein is necessary for storage in secretory granules and facilitates exit from the endoplasmic reticulum". J. Biol. Chem. 267 (18): 13093–100. 1992. doi:10.1016/S0021-9258(18)42385-X. PMID 1618808. 
• "Length Polymorphisms in Human Proline-Rich Protein Genes Generated by Intragenic Unequal Crossing over". Genetics 120 (1): 267–78. 1989. doi:10.1093/genetics/120.1.267. PMID 2851479. 
• "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system". J. Biol. Chem. 260 (20): 11123–30. 1985. doi:10.1016/S0021-9258(17)39156-1. PMID 2993301. 
• "Basic proline-rich proteins from human parotid saliva: complete covalent structures of proteins IB-1 and IB-6". Biochemistry 25 (9): 2387–92. 1986. doi:10.1021/bi00357a013. PMID 3521730. 
• "Clones from the human gene complex coding for salivary proline-rich proteins". Proc. Natl. Acad. Sci. U.S.A. 81 (17): 5561–5. 1984. doi:10.1073/pnas.81.17.5561. PMID 6089212. Bibcode: 1984PNAS...81.5561A. 
• "Further fractionation of basic proline-rich peptides from human parotid saliva and complete amino acid sequence of basic proline-rich peptide P-H". J. Biochem. 94 (6): 1991–9. 1984. doi:10.1093/oxfordjournals.jbchem.a134553. PMID 6671974. 
• "Basic proline-rich proteins from human parotid saliva: complete covalent structure of protein IB-9 and partial structure of protein IB-6, members of a polymorphic pair". Biochemistry 21 (25): 6558–62. 1983. doi:10.1021/bi00268a036. PMID 6924859. 
• "Fractionation and characterization of basic proline-rich peptides of human parotid saliva and the amino acid sequence of proline-rich peptide P-E". J. Biochem. 91 (6): 2067–75. 1982. doi:10.1093/oxfordjournals.jbchem.a133900. PMID 7118863. 
• "The structure and evolution of the human salivary proline-rich protein gene family". Mamm. Genome 4 (1): 3–14. 1993. doi:10.1007/BF00364656. PMID 8422499. 
• "Enhanced Glycosylation and Sulfation of Secretory Proteoglycans Is Coupled to the Expression of a Basic Secretory Protein". Mol. Biol. Cell 9 (3): 575–83. 1998. doi:10.1091/mbc.9.3.575. PMID 9487127. 
• "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. 2001. doi:10.1038/88107. PMID 11329013. 
• "Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases". Eur. J. Biochem. 268 (12): 3423–31. 2001. doi:10.1046/j.1432-1327.2001.02241.x. PMID 11422372. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.