Biology:Outline of life extension

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Short description: Overview of and topical guide to life extension


The following outline is provided as an overview of and topical guide to life extension:

Life extension – study of slowing down or reversing the processes of aging to extend both the maximum and average lifespan. Also known as anti-aging medicine, experimental gerontology, and biomedical gerontology.


Goals

Longevity

Strategies

Research and development

Available strategies

  • Calorie restriction or protein restriction or intermittent fasting
  • Exercise
  • Geroprotector
  • Senolytics

Potential future strategies

Aging

Hallmarks of aging

  • Altered intercellular communication
  • Cellular senescence
  • Deregulated nutrient sensing
  • Epigenetic alterations
  • Genomic instability
  • Loss of proteostasis
  • Mitochondrial dysfunction
  • Stem cell exhaustion
  • Telomere attrition

Causes of aging

  • Cross-links
  • Free radicals – atom, molecule, or ion that has unpaired valence electrons. With some exceptions, these unpaired electrons make free radicals highly chemically reactive towards other substances, or even towards themselves: their molecules will often spontaneously dimerize or polymerize if they come in contact with each other. They are countered to some extent by antioxidants.
  • Glycation
  • Lipofuscin
  • Viral infections (acute or chronic)

Theories of aging

Theories of aging

Organizations

  • Alcor Life Extension Foundation
  • Altos Labs
  • Alliance for Aging Research
  • American Academy of Anti-Aging Medicine
  • American Aging Association
  • BioViva
  • Buck Institute for Research on Aging
  • Calico
  • Cryonics Institute
  • International Longevity Alliance
  • LEV Foundation[1]
  • Life Extension Advocacy Foundation
  • Life Extension Foundation
  • Methuselah Foundation – non-profit organization dedicated to extending the healthy human lifespan by advancing tissue engineering and regenerative medicine therapies. It was co-founded in 2003 by Aubrey de Grey and David Gobel, and is based in Springfield, Virginia, United States.
  • SENS Research Foundation – 501(c)(3) non-profit organization co-founded by Michael Kope, Aubrey de Grey, Jeff Hall, Sarah Marr and Kevin Perrott, which is based in Mountain View, California, United States. Its activities include research programs and public relations work for the application of regenerative medicine to aging.

Notable people

  • Aubrey de Grey
  • Leonard Hayflick
  • Zoltan Istvan
  • Saul Kent
  • Cynthia Kenyon
  • Durk Pearson
  • Sandy Shaw
  • David Andrew Sinclair
  • Roy Walford
  • Michael D. West

See also

References

  1. ↑ Garth, Eleanor (2022-10-28). "Aubrey de Grey on longevity at scale" (in en-GB). Longevity.Technology - Latest News, Opinions, Analysis and Research. https://longevity.technology/news/aubrey-de-grey-on-longevity-at-scale. 

Further reading

  • Ending Aging, a 2007 book which describes Aubrey de Grey's medical proposal for defeating aging (i.e. SENS).

External links



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