Biology:L-threonine 3-dehydrogenase

From HandWiki
Short description: Class of enzymes
L-threonine 3-dehydrogenase
2ejv.jpg
L-threonine 3-dehydrogenase homotetramer, Thermus thermophilus
Identifiers
EC number1.1.1.103
CAS number9067-99-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
L-Threonine dehydrogenase
Identifiers
SymbolTDH
NCBI gene157739
HGNC15547
RefSeqNM_152566
UniProtQ8IZJ6
Other data
EC number1.1.1.103
LocusChr. 8 p23.1

In enzymology, a L-threonine 3-dehydrogenase (EC 1.1.1.103) is an enzyme that catalyzes the chemical reaction

L-threonine + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] L-2-amino-3-oxobutanoate + NADH + H+

Thus, the two substrates of this enzyme are L-threonine and NAD+, whereas its 3 products are L-2-amino-3-oxobutanoate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-threonine:NAD+ oxidoreductase. Other names in common use include L-threonine dehydrogenase, threonine 3-dehydrogenase, and threonine dehydrogenase. This enzyme participates in glycine, serine and threonine metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2D8A, 2DFV, and 2DQ4.

References