Biology:Keratin 17

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Keratin, type I cytoskeletal 17 is a protein that in humans is encoded by the KRT17 gene.[1][2][3][4]

Keratin 17 is a type I cytokeratin. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in the gene encoding this protein lead to PC-K17 (previously known as Jackson-Lawler) type pachyonychia congenita and steatocystoma multiplex.[4]

Interactions

Keratin 17 has been shown to interact with CCDC85B.[5]

References

  1. "Keratin 16 and keratin 17 mutations cause pachyonychia congenita". Nat Genet 9 (3): 273–8. Jul 1995. doi:10.1038/ng0395-273. PMID 7539673. 
  2. "Characterization of the human gene encoding cytokeratin 17 and its expression pattern". Eur J Cell Biol 59 (1): 127–37. Jan 1993. PMID 1281771. 
  3. "New consensus nomenclature for mammalian keratins". J Cell Biol 174 (2): 169–74. Jul 2006. doi:10.1083/jcb.200603161. PMID 16831889. 
  4. 4.0 4.1 "Entrez Gene: KRT17 keratin 17". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3872. 
  5. "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode2005Natur.437.1173R. 

Further reading

External links