Biology:Jumping translocation breakpoint

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example
Jumping translocation breakpoint protein (JTB)
Identifiers
SymbolJTB
PfamPF05439
InterProIPR008657

The jumping translocation breakpoint protein (JTB), also known as prostate androgen-regulated protein (PAR), is a protein that in humans is encoded by the JTB gene.[1][2] It is an orphan receptor with unknown function.[3]

The JTB family of proteins contains several jumping translocation breakpoint proteins or JTBs. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JTB has been found to fuse with the telomeric repeats of acceptor telomeres in a case of JT. Homo sapiens JTB (hJTB) encodes a transmembrane protein that is highly conserved among divergent eukaryotic species. JT results in a hJTB truncation, which potentially produces an hJTB product devoid of the transmembrane domain. hJTB is located in a gene-rich region at 1q21, called epidermal differentiation complex (EDC).[1] JTB has also been implicated in prostatic carcinomas.[4]

References

  1. 1.0 1.1 "JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation". Oncogene 18 (12): 2085–90. Jun 1999. doi:10.1038/sj.onc.1202510. PMID 10321732. 
  2. "Entrez Gene: JTB jumping translocation breakpoint". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10899. 
  3. Rousseau, Francois; Pan, Borlan; Fairbrother, Wayne J.; Bazan, J. Fernando; Lingel, Andreas (January 2012). "The Structure of the Extracellular Domain of the Jumping Translocation Breakpoint Protein Reveals a Variation of the Midkine Fold". Journal of Molecular Biology 415 (1): 22–28. doi:10.1016/j.jmb.2011.10.048. PMID 22079049. 
  4. "PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells". Int. J. Oncol. 16 (5): 1055–61. May 2000. doi:10.3892/ijo.16.5.1055. PMID 10762645. 

Further reading

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein JTB


This article incorporates text from the public domain Pfam and InterPro: IPR008657