Biology:Herpesvirus entry mediator
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Herpesvirus entry mediator (HVEM), also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), is a human cell surface receptor of the TNF-receptor superfamily[1][2][3][4] encoded by the TNFRSF14 gene.[3]
Nomenclature
This protein was originally known as herpesvirus entry mediator A (HveA); HveB and HveC are structurally unrelated proteins of the immunoglobulin superfamily. It is also known as CD270 in the cluster of differentiation classification. Moreover, it is also referred to as ATAR (another TRAF-associated receptor).
Function
The protein encoded by this gene is a member of the TNF-receptor superfamily. The cytoplasmic region of this receptor was found to bind to several TNF receptor associated factor (TRAF) family members, which may mediate the signal transduction pathways that activate the immune response.[3]
In melanocytic cells TNFRSF14 gene expression may be regulated by MITF.[5]
Interactions
TNFRSF14 has been shown to interact with TRAF2,[6][7] TNFSF14[8][9] and TRAF5.[6][7]
Clinical relevance
Mutations in this gene have been recurrently been associated to cases of diffuse large B-cell lymphoma[10][11] and pediatric-type follicular lymphoma.[12]
This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism.[3]
References
- ↑ "Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family". Cell 87 (3): 427–36. November 1996. doi:10.1016/S0092-8674(00)81363-X. PMID 8898196.
- ↑ "A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation". The Journal of Biological Chemistry 272 (22): 14272–6. May 1997. doi:10.1074/jbc.272.22.14272. PMID 9162061.
- ↑ 3.0 3.1 3.2 3.3 "TNFRSF14 TNF receptor superfamily member 14 [ Homo sapiens (human) "]. National Library of Medicine, National Center for Biotechnology Information. 23 November 2023. https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8764.
- ↑ Ware, Carl (2008). "Chapter 25: TNF-Related Cytokines in Immunity". in Paul, William. Fundamental Immunology (Book) (6th ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 776–801. ISBN 978-0-7817-6519-0.
- ↑ "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research 21 (6): 665–76. December 2008. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
- ↑ 6.0 6.1 "ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5". The Journal of Biological Chemistry 272 (21): 13471–4. May 1997. doi:10.1074/jbc.272.21.13471. PMID 9153189.
- ↑ 7.0 7.1 "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". The Journal of Biological Chemistry 272 (22): 14029–32. May 1997. doi:10.1074/jbc.272.22.14029. PMID 9162022.
- ↑ "Modulation of T-cell responses to alloantigens by TR6/DcR3". The Journal of Clinical Investigation 107 (11): 1459–68. June 2001. doi:10.1172/JCI12159. PMID 11390428.
- ↑ "A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis". The Journal of Biological Chemistry 274 (20): 13733–6. May 1999. doi:10.1074/jbc.274.20.13733. PMID 10318773.
- ↑ "Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma". Nature 476 (7360): 298–303. August 2011. doi:10.1038/nature10351. PMID 21796119. Bibcode: 2011Natur.476..298M.
- ↑ "Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing". Proceedings of the National Academy of Sciences of the United States of America 109 (10): 3879–84. March 2012. doi:10.1073/pnas.1121343109. PMID 22343534. Bibcode: 2012PNAS..109.3879L.
- ↑ "Pediatric-type Follicular Lymphoma and Pediatric Nodal Marginal Zone Lymphoma: Recent Clinical, Morphologic, Immunophenotypic, and Genetic Insights". Advances in Anatomic Pathology 24 (3): 128–135. May 2017. doi:10.1097/PAP.0000000000000144. PMID 28277421.
Further reading
- "ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5". The Journal of Biological Chemistry 272 (21): 13471–4. May 1997. doi:10.1074/jbc.272.21.13471. PMID 9153189.
- "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". The Journal of Biological Chemistry 272 (22): 14029–32. May 1997. doi:10.1074/jbc.272.22.14029. PMID 9162022.
- "LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator". Immunity 8 (1): 21–30. January 1998. doi:10.1016/S1074-7613(00)80455-0. PMID 9462508.
- "Cloning and characterization of mouse RIP140, a corepressor for nuclear orphan receptor TR2". Molecular and Cellular Biology 18 (11): 6745–55. November 1998. doi:10.1128/mcb.18.11.6745. PMID 9774688.
- "APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death". Cancer Research 60 (4): 1021–7. February 2000. PMID 10706119.
- "Modulation of T-cell responses to alloantigens by TR6/DcR3". The Journal of Clinical Investigation 107 (11): 1459–68. June 2001. doi:10.1172/JCI12159. PMID 11390428.
- "The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases". Molecular Endocrinology 15 (8): 1318–28. August 2001. doi:10.1210/mend.15.8.0682. PMID 11463856.
- "Herpes simplex virus glycoprotein D bound to the human receptor HveA". Molecular Cell 8 (1): 169–79. July 2001. doi:10.1016/S1097-2765(01)00298-2. PMID 11511370.
- "Tumor necrosis factor receptor and ligand superfamily family members TNFRSF14 and LIGHT: new players in human atherogenesis". Arteriosclerosis, Thrombosis, and Vascular Biology 21 (12): 1873–5. December 2001. doi:10.1161/atvb.21.12.1873. PMID 11742858.
- "Search for polymorphisms in the genes for herpesvirus entry mediator, nectin-1, and nectin-2 in immune seronegative individuals". The Journal of Infectious Diseases 185 (1): 36–44. January 2002. doi:10.1086/338116. PMID 11756979.
- "Crystallization and preliminary diffraction studies of the ectodomain of the envelope glycoprotein D from herpes simplex virus 1 alone and in complex with the ectodomain of the human receptor HveA". Acta Crystallographica Section D 58 (Pt 5): 836–8. May 2002. doi:10.1107/S0907444902001270. PMID 11976496.
- "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor". The Journal of Biological Chemistry 277 (37): 33571–9. September 2002. doi:10.1074/jbc.M203531200. PMID 12093804.
- "Differential expression of LIGHT and its receptors in human placental villi and amniochorion membranes". The American Journal of Pathology 161 (6): 2011–7. December 2002. doi:10.1016/S0002-9440(10)64479-3. PMID 12466117.
- "Specific association of glycoprotein B with lipid rafts during herpes simplex virus entry". Journal of Virology 77 (17): 9542–52. September 2003. doi:10.1128/JVI.77.17.9542-9552.2003. PMID 12915568.
- "High levels of soluble herpes virus entry mediator in sera of patients with allergic and autoimmune diseases". Experimental & Molecular Medicine 35 (6): 501–8. December 2003. doi:10.1038/emm.2003.65. PMID 14749527.
- "Comparative usage of herpesvirus entry mediator A and nectin-1 by laboratory strains and clinical isolates of herpes simplex virus". Virology 322 (2): 286–99. May 2004. doi:10.1016/j.virol.2004.02.005. PMID 15110526.
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