Biology:Gelatinase biosynthesis-activating pheromone
From HandWiki
| Gelatinase biosynthesis activating pheromone | |||||||
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| Symbol | fsrD | ||||||
| UniProt | G8ADN7 | ||||||
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Gelatinase biosynthesis-activating pheromone abbreviated as GBAP is a cyclic peptide produced by pathogenic bacteria such as Enterococcus faecalis.[1] GAP is part of the quorum sensing system of certain bacteria where it positively regulates the expression of gelatinase and serine proteases that are under the control of the gelE-sprE operon.[2]
GBAP is an 11-amino-acid-residue cyclic peptide containing a lactone linkage between the C-terminal carboxylic acid group and a serine side chain hydroxyl group.[2]
References
- ↑ "The incongruent gelatinase genotype and phenotype in Enterococcus faecalis are due to shutting off the ability to respond to the gelatinase biosynthesis-activating pheromone (GBAP) quorum-sensing signal". Microbiology 158 (Pt 2): 519–28. 2012. doi:10.1099/mic.0.055574-0. PMID 22117005.
- ↑ 2.0 2.1 "Structure-activity relationship of gelatinase biosynthesis-activating pheromone of Enterococcus faecalis". J. Bacteriol. 191 (2): 641–50. 2009. doi:10.1128/JB.01029-08. PMID 18996993.
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