Biology:GABRG2

From HandWiki
A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Gamma-aminobutyric acid receptor subunit gamma-2 is a protein that in humans is encoded by the GABRG2 gene.

Function

Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain, mediates neuronal inhibition by binding to GABA receptors. The type A GABA receptors are pentameric chloride channels assembled from among many genetic variants of GABA(A) subunits. This gene encodes the gamma 2 subunit of GABA(A) receptor. Mutations in this gene have been associated with epilepsy and febrile seizures. Alternative splicing of this gene results in transcript variants encoding different isoforms.[1]

Interactions

GABRG2 has been shown to interact with GABARAP[2][3][4] and Dopamine receptor D5.[5]

See also

References

  1. "Entrez Gene: GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2566. 
  2. "Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors". Journal of Neurochemistry 80 (5): 815–823. March 2002. doi:10.1046/j.0022-3042.2002.00762.x. PMID 11948245. 
  3. "Structure of GABARAP in two conformations: implications for GABA(A) receptor localization and tubulin binding". Neuron 33 (1): 63–74. January 2002. doi:10.1016/S0896-6273(01)00558-X. PMID 11779480. 
  4. "GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton". Nature 397 (6714): 69–72. January 1999. doi:10.1038/16264. PMID 9892355. 
  5. "Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors". Nature 403 (6767): 274–280. January 2000. doi:10.1038/35002014. PMID 10659839. Bibcode2000Natur.403..274L. 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.