Biology:FKBP4

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Short description: Protein-coding gene in humans


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

FK506-binding protein 4 is a protein that in humans is encoded by the FKBP4 gene.[1][2]

Function

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy.[2]

Structure

This protein contains TPR repeats and has a PPlase domain.

Clinical significance

Recent research suggests that FKBP4 may play a role in preventing the Tau protein from turning pathogenic. This may prove significant for the development of new Alzheimer's drugs and for detecting the disease before the onset of clinical symptoms.[3]

Interactions

FKBP4 has been shown to interact with GLMN.[4][5]

See also

References

  1. "Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes". Proceedings of the National Academy of Sciences of the United States of America 89 (22): 10974–8. November 1992. doi:10.1073/pnas.89.22.10974. PMID 1279700. Bibcode1992PNAS...8910974P. 
  2. 2.0 2.1 "Entrez Gene: FKBP4 FK506 binding protein 4, 59kDa". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2288. 
  3. "The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease". Journal of Neurochemistry 133 (1): 1–13. April 2015. doi:10.1111/jnc.13033. PMID 25628064. 
  4. "FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin". The Journal of Biological Chemistry 271 (51): 32923–9. December 1996. doi:10.1074/jbc.271.51.32923. PMID 8955134. 
  5. "Mutation of FKBP associated protein 48 (FAP48) at proline 219 disrupts the interaction with FKBP12 and FKBP52". Regulatory Peptides 97 (2–3): 147–52. March 2001. doi:10.1016/S0167-0115(00)00206-8. PMID 11164950. 
  6. Prakash, Ajit; Shin, Joon; Rajan, Sreekanth; Yoon, Ho Sup (2016-04-07). "Structural basis of nucleic acid recognition by FK506-binding protein 25 (FKBP25), a nuclear immunophilin". Nucleic Acids Research 44 (6): 2909–2925. doi:10.1093/nar/gkw001. ISSN 0305-1048. PMID 26762975. 

Further reading

External links