Biology:Estradiol 17beta-dehydrogenase

From HandWiki
estradiol 17-beta-dehydrogenase
Identifiers
EC number1.1.1.62
CAS number9028-61-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, an estradiol 17beta-dehydrogenase (EC 1.1.1.62) is an enzyme that catalyzes the chemical reaction

estradiol-17beta + NAD(P)+ [math]\displaystyle{ \rightleftharpoons }[/math] estrone + NAD(P)H + H+

The 3 substrates of this enzyme are estradiol-17beta, NAD+, and NADP+, whereas its 4 products are estrone, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is estradiol-17beta:NAD(P)+ 17-oxidoreductase. Other names in common use include 20alpha-hydroxysteroid dehydrogenase, 17beta,20alpha-hydroxysteroid dehydrogenase, 17beta-estradiol dehydrogenase, estradiol dehydrogenase, estrogen 17-oxidoreductase, and 17beta-HSD. This enzyme participates in androgen and estrogen metabolism.

Structural studies

As of late 2007, 29 structures have been solved for this class of enzymes, with PDB accession codes 1A27, 1BHS, 1DHT, 1EQU, 1FDS, 1FDT, 1FDU, 1FDV, 1FDW, 1GZ6, 1I5R, 1IKT, 1IOL, 1JTV, 1QYV, 1QYW, 1QYX, 1S1P, 1S1R, 1S2A, 1S2C, 1XF0, 1YB1, 1ZQ5, 2F38, 2FGB, 2HQ1, 2PD6, and 3DHE.

References

  • "17β-Estradiol Dehydrogenase of Ovine Ovaries". J. Biol. Chem. 245 (8): 1978–84. 1970. PMID 4314937. 
  • "Human Placental Estradiol-17β Dehydrogenase. II. Kinetics and substrate specificities". J. Biol. Chem. 234: 2609–14. 1959. PMID 14413943.