Biology:Escherichia coli NC101
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Escherichia coli (AIEC) NC101 is a mouse isolate, serotype O2:H6/41, that is pro-carcinogenic, adherent-invasive (AIEC), probiotic strain of Escherichia coli, a species of bacteria that thrives in the intestines of mammals.[1][2] NC101 has also been identified as a nicotinic acid (NA) auxotroph, a pathobiont, which is an organism that is harmful under certain circumstances,[3] and is an important, relevant model organism that demonstrates how susceptible individuals may produce inappropriate immune responses to seemingly benign intestinal E. coli.[4]
History
NC101 was first isolated and found from a specific pathogen-free wild-type mouse at the North Carolina State University between 2004 and 2005.[5] Sequencing of NC101 showed it has a missense mutation in nadA, a gene that encodes for quinolinate synthase A, which is necessary for de novo nicotinamide adenine dinucleotide (NAD) biosynthesis.[4]
Effects
E. coli NC101 has been found to promote carcinoma specifically, mucinous adenocarcinoma, in while performing experiments in azoxymethane treated mice. The findings of the study found "...tumorigenesis by altering microbial composition and inducing the expansion of microorganisms with genotoxic capabilities."[6] The frequency of specific E. coli strains like NC101 in laboratory mouse colonies is currently unknown.[citation needed]
See also
References
- ↑ Sadecki, Patric W.; Balboa, Samantha J.; Lopez, Lacey R.; Kedziora, Katarzyna M.; Arthur, Janelle C.; Hicks, Leslie M. (2021-07-16). "Evolution of Polymyxin Resistance Regulates Colibactin Production in Escherichia coli". ACS Chemical Biology 16 (7): 1243–1254. doi:10.1021/acschembio.1c00322. ISSN 1554-8929. PMID 34232632. PMC 8601121. https://doi.org/10.1021/acschembio.1c00322.
- ↑ García, Alexis; Mannion, Anthony; Feng, Yan; Madden, Carolyn M.; Bakthavatchalu, Vasudevan; Shen, Zeli; Ge, Zhongming; Fox, James G. (December 2016). "Cytotoxic Escherichia coli strains encoding colibactin colonize laboratory mice". Microbes and Infection 18 (12): 777–786. doi:10.1016/j.micinf.2016.07.005. ISSN 1286-4579. PMID 27480057. PMC 5182106. http://dx.doi.org/10.1016/j.micinf.2016.07.005.
- ↑ Jochum, Lara; Stecher, Bärbel (2020-10-01). "Label or Concept – What Is a Pathobiont?" (in en). Trends in Microbiology 28 (10): 789–792. doi:10.1016/j.tim.2020.04.011. ISSN 0966-842X. PMID 32376073.
- ↑ 4.0 4.1 Lopez, Lacey R.; Barlogio, Cassandra J.; Broberg, Christopher A.; Wang, Jeremy; Arthur, Janelle C. (2021). "A nadA Mutation Confers Nicotinic Acid Auxotrophy in Pro-carcinogenic Intestinal Escherichia coli NC101". Frontiers in Microbiology 12: 1081. doi:10.3389/fmicb.2021.670005. ISSN 1664-302X. PMID 34149655.
- ↑ Kim, Sandra C.; Tonkonogy, Susan L.; Albright, Carol A.; Tsang, Julia; Balish, Edward J.; Braun, Jonathon; Huycke, Mark M.; Sartor, R. Balfour (2005). "Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria". Gastroenterology 128 (4): 891–906. doi:10.1053/j.gastro.2005.02.009. PMID 15825073. https://cdr.lib.unc.edu/downloads/pk02cm00r.
- ↑ Arthur, Janelle C.; Perez-Chanona, Ernesto; Mühlbauer, Marcus; Tomkovich, Sarah; Uronis, Joshua M.; Fan, Ting-Jia; Campbell, Barry J.; Abujamel, Turki et al. (2012-10-05). "Intestinal inflammation targets cancer-inducing activity of the microbiota". Science 338 (6103): 120–123. doi:10.1126/science.1224820. ISSN 0036-8075. PMID 22903521. Bibcode: 2012Sci...338..120A.
Wikidata ☰ Q110231207 entry
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