Biology:ERG3
From HandWiki
| Sterol C-5 desaturase | |
|---|---|
| Identifiers | |
| Organism | |
| Symbol | ERG3 |
| Alt. symbols | SC5D, SYR1 |
| Entrez | 850745 |
| HomoloGene | 5044 |
| RefSeq (mRNA) | NM_001181943 |
| Other data | |
| EC number | 1.14.19.20 |
| Chromosome | XII: 0.25 - 0.25 Mb |
ERG3 or sterol C-5 desaturase is a fungal enzyme originally from Saccharomyces cerevisiae, the human ortholog of ERG3 is SC5D.[1] ERG3 localizes to both the endoplasmic reticulum and vesicles,[2][3] catalyzes the C5(6)-dehydrogenation of episterol to 5-dehydroepisterol, 5-Dehydroepisterol will be further converted into ergosterol.[4][5]
See also
References
- ↑ "The physiological roles of membrane ergosterol as revealed by the phenotypes of syr1/erg3 null mutant of Saccharomyces cerevisiae". Bioscience, Biotechnology, and Biochemistry 59 (3): 482–6. March 1995. doi:10.1271/BBB.59.482. PMID 7766188.
- ↑ "The spatial organization of lipid synthesis in the yeast Saccharomyces cerevisiae derived from large scale green fluorescent protein tagging and high resolution microscopy". Molecular & Cellular Proteomics 4 (5): 662–72. May 2005. doi:10.1074/mcp.M400123-MCP200. PMID 15716577.
- ↑ "The cytochrome b5 dependent C-5(6) sterol desaturase DES5A from the endoplasmic reticulum of Tetrahymena thermophila complements ergosterol biosynthesis mutants in Saccharomyces cerevisiae". Steroids 77 (13): 1313–20. November 2012. doi:10.1016/j.steroids.2012.08.015. PMID 22982564.
- ↑ "Functional characterization of the Chlamydomonas reinhardtii ERG3 ortholog, a gene involved in the biosynthesis of ergosterol". PLOS ONE 5 (1): e8659. January 2010. doi:10.1371/journal.pone.0008659. PMID 20084111. Bibcode: 2010PLoSO...5.8659B.
- ↑ "Fluconazole treatment is effective against a Candida albicans erg3/erg3 mutant in vivo despite in vitro resistance". Antimicrobial Agents and Chemotherapy 50 (2): 580–6. February 2006. doi:10.1128/AAC.50.2.580-586.2006. PMID 16436713.
- ↑ "The Arabidopsis dwf7/ste1 mutant is defective in the delta7 sterol C-5 desaturation step leading to brassinosteroid biosynthesis". The Plant Cell 11 (2): 207–21. February 1999. doi:10.1105/tpc.11.2.207. PMID 9927639.
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