Biology:Cysteine lyase
| cysteine lyase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.4.1.10 | ||||||||
| CAS number | 9079-86-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme cysteine lyase (EC 4.4.1.10) [1] catalyzes the chemical reaction
- L-cysteine + sulfite [math]\displaystyle{ \rightleftharpoons }[/math] L-cysteate + hydrogen sulfide
This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is L-cysteine hydrogen-sulfide-lyase (adding sulfite; L-cysteate-forming). Other names in common use include cysteine (sulfite) lyase, and L-cysteine hydrogen-sulfide-lyase (adding sulfite). This enzyme participates in cysteine and taurine metabolism. It employs one cofactor, pyridoxal phosphate.
Evolution
Genes encoding cysteine lyase (CL) originated around 300 million years ago by a tandem gene duplication and neofunctionalization of cystathionine β-lyase (CBS) shortly after the split of mammalian and reptilian lineages. CL genes are found only in Sauropsida where they are involved in a metabolic pathway for sulfur metabolism in the chicken egg.[2]
References
- ↑ "Reactions catalysed by cysteine lyase from the yolk sac of chicken embryo". Biochim. Biophys. Acta 171 (2): 369–71. 1969. doi:10.1016/0005-2744(69)90174-0. PMID 5813025.
- ↑ "Birth of a pathway for sulfur metabolism in early amniote evolution". Nat Ecol Evol 4 (9): 1239–1246. 2020. doi:10.1038/s41559-020-1232-4. PMID 32601391.
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