Biology:Crc (protein)
From HandWiki
| Crc | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Crystal structure of Crc in Pseudomonas aeruginosa.[1] | |||||||||
| Identifiers | |||||||||
| Symbol | Crc | ||||||||
| Pfam | PF03372 | ||||||||
| CDD | cd08372 | ||||||||
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The Catabolite repression control (Crc) protein participates in suppressing expression of several genes involved in utilization of carbon sources in Pseudomonas bacteria.[2] Presence of organic acids triggers activation of Crc and in conjunction with the Hfq protein genes that metabolize a given carbon source are downregulated until another more favorable carbon source is depleted.[3] Crc-mediated regulation impact processes such as biofilm formation,[4] virulence[5] and antibiotic susceptibility.[6]
Interactions
Hfq and Crc bind to A-rich sequences in the ribosome binding sites of genes that code for carbon utilization enzymes and consequently suppress their translation.[7]
References
- ↑ "Structure analysis of the global metabolic regulator Crc from Pseudomonas aeruginosa". IUBMB Life 65 (1): 50–7. January 2013. doi:10.1002/iub.1103. PMID 23281037.
- ↑ Ramos, Juan-Luis (2004-06-17) (in en). Virulence and Gene Regulation. Springer Science & Business Media. ISBN 978-0-306-48376-9. https://books.google.com/books?id=wDnyTsi_LKAC&dq=Catabolite+repression+control&pg=PA365.
- ↑ "Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa carbon catabolite repression". PLOS Genetics 10 (6): e1004440. June 2014. doi:10.1371/journal.pgen.1004440. PMID 24945892.
- ↑ O'Toole, GA; Gibbs, KA; Hager, PW; Phibbs, PV jr; Kolter, R (2000). "The global carbon metabolism regulator Crc is a component of a signal transduction pathway required for biofilm development by Pseudomonas aeruginosa.". J Bacteriol 182 (2): 425–431. doi:10.1128/jb.182.2.425-431.2000. PMID 10629189.
- ↑ "The catabolite repression control protein Crc plays a role in the development of antimicrobial-tolerant subpopulations in Pseudomonas aeruginosa biofilms". Microbiology 158 (Pt 12): 3014–9. December 2012. doi:10.1099/mic.0.061192-0. PMID 23023972.
- ↑ "The sensor kinase CbrA is a global regulator that modulates metabolism, virulence, and antibiotic resistance in Pseudomonas aeruginosa". Journal of Bacteriology 193 (4): 918–31. February 2011. doi:10.1128/jb.00911-10. PMID 21169488.
- ↑ "Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa carbon catabolite repression". PLOS Genetics 10 (6): e1004440. June 2014. doi:10.1371/journal.pgen.1004440. PMID 24945892.
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