Biology:CYP4Z1
 Generic protein structure example |
CYP4Z1 (cytochrome P450, family 4, subfamily Z, polypeptide 1) is a protein that in humans is encoded by the CYP4Z1 gene.[1]
Function
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33.[2]
Clinical significance
CYP4Z1 is overexpressed in breast cancer cells.[1] It has also been demonstrated that the expression of the CYP4Z1 gene is upregulated by activated glucocorticoid and progesterone receptors.[3] The overexpression of CYP4Z1 is associated with the breast cancer cells' increased production of 20-Hydroxyeicosatetraenoic acid (20-HETE); it is hypothesized that CYP4Z1 metabolizes arachidonic acid to 20-HETE and that this overproduction is responsible for increasing the growth and spread of breast cancer cells in human breast cancer.[4][5] CPZ4Z1 is likewise overexpressed in ovarian cancer cells.[5] These studies also suggest that CYP4Z1 will be a valuable marker to distinguish between benign and malignant breast and ovarian growths in humans and/or the prognoses of malignant growths in these tissues.
References
- ↑ 1.0 1.1 "Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma". Cancer Res. 64 (7): 2357–64. April 2004. doi:10.1158/0008-5472.CAN-03-0849. PMID 15059886.
- ↑ Template:NCBI RefSeq
- ↑ "Conditional regulation of the human CYP4X1 and CYP4Z1 genes". Arch. Biochem. Biophys. 436 (2): 377–85. April 2005. doi:10.1016/j.abb.2005.02.022. PMID 15797250.
- ↑ "Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer". Toxicology and Applied Pharmacology 264 (1): 73–83. Oct 2012. doi:10.1016/j.taap.2012.07.019. PMID 22841774.
- ↑ 5.0 5.1 "The 3'UTR of the pseudogene CYP4Z2P promotes tumor angiogenesis in breast cancer by acting as a ceRNA for CYP4Z1". Breast Cancer Research and Treatment 150 (1): 105–18. Feb 2015. doi:10.1007/s10549-015-3298-2. PMID 25701119.
Further reading
- "Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid". Biological Chemistry 390 (4): 313–7. Apr 2009. doi:10.1515/BC.2009.030. PMID 19090726.
- "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics 14 (1): 1–18. Jan 2004. doi:10.1097/00008571-200401000-00001. PMID 15128046.
- "The cytochrome P450 4 (CYP4) family". General Pharmacology 28 (3): 351–9. Mar 1997. doi:10.1016/S0306-3623(96)00246-7. PMID 9068972.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |  |
