Biology:CXCL17
| chemokine (C-X-C motif) ligand 7 | |
|---|---|
| Identifiers | |
| Symbol | CXCL17 |
| Alt. symbols | SCYB17, VCC-1, DMC |
| NCBI gene | 284340 |
| RefSeq | NM_198477 |
| UniProt | Q6UXB2 |
| Other data | |
| Locus | Chr. 19 q13.2 |
Chemokine (C-X-C motif) ligand 17 (CXCL17) is a small cytokine belonging to the CXC chemokine family that has been identified in humans and mice. CXCL17 attracts dendritic cells and monocytes and is regulated in tumors. It is also known as VEGF co-regulated chemokine 1 (VCC-1) and dendritic cell- and monocyte-attracting chemokine-like protein (DMC).[1][2] This chemokine is constitutively expressed in the lung.[2] The gene for human CXCL17 is located on chromosome 19.[2]
CXCL17 is an orphan chemokine with no known receptor.[3]
Receptor
The receptor for CXCL17 is likely to be a G protein-coupled receptor (GPCR).[4]
The GPCR GPR35 was thought to be a receptor of CXCL17.[5] Subsequent research has suggested that GPR35 is not a receptor for CXCL17.[3][6]
References
- ↑ "VCC-1, a novel chemokine, promotes tumor growth". Biochemical and Biophysical Research Communications 350 (1): 74–81. November 2006. doi:10.1016/j.bbrc.2006.08.194. PMID 16989774.
- ↑ 2.0 2.1 2.2 "Cutting edge: novel human dendritic cell- and monocyte-attracting chemokine-like protein identified by fold recognition methods". Journal of Immunology 176 (4): 2069–73. February 2006. doi:10.4049/jimmunol.176.4.2069. PMID 16455961.
- ↑ 3.0 3.1 "Evidence for the Existence of a CXCL17 Receptor Distinct from GPR35". Journal of Immunology 201 (2): 714–724. June 2018. doi:10.4049/jimmunol.1700884. PMID 29875152.
- ↑ "CXCL17 is a major chemotactic factor for lung macrophages". Journal of Immunology 193 (3): 1468–74. August 2014. doi:10.4049/jimmunol.1400551. PMID 24973458.
- ↑ "Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17". Journal of Immunology 194 (1): 29–33. January 2015. doi:10.4049/jimmunol.1401704. PMID 25411203.
- ↑ "GPR35 mediates lodoxamide-induced migration inhibitory response but not CXCL17-induced migration stimulatory response in THP-1 cells; is GPR35 a receptor for CXCL17?". British Journal of Pharmacology 175 (1): 154–161. January 2018. doi:10.1111/bph.14082. PMID 29068046.
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