Biology:CSNK1E

Generic protein structure example

Casein kinase I isoform epsilon is an enzyme that in humans is encoded by the CSNK1E gene.

Function

The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate proteins of the Period family of circadian rhythm proteins. A homolog of this mammalian protein can be found in Drosophila melanogaster. Known as doubletime, this protein also plays a role in the phosphorylation of proteins involved in circadian rhythms. Two transcript variants encoding the same protein have been found for this gene.

Interactions

CSNK1E has been shown to interact with PER1 and AXIN1.

Inhibitors

Selective

• PF-4800567

Non-selective

• PF-670462 (also inhibits CK1-δ)

See also

• Casein kinase 1 isoform epsilon
• Casein kinase 1 family

External links

• Human CSNK1E genome location and CSNK1E gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Casein kinase I isoform epsilon (CSNK1E)