Biology:CMP kinase

From HandWiki
Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

UMP-CMP kinase is an enzyme that in humans is encoded by the CMPK1 gene.[1][2]

Function

Uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. These nucleoside diphosphates are required for cellular nucleic acid synthesis.[2][3]

References

  1. "Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme". Molecular Pharmacology 56 (3): 562–9. 1999. doi:10.1124/mol.56.3.562. PMID 10462544. 
  2. 2.0 2.1 EntrezGene 51727
  3. "Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates". Cancer Research 62 (6): 1624–31. 2002. PMID 11912132. 

External links

Further reading