Biology:CDR132L
From HandWiki
CDR132L is an antisense RNA therapy that inhibits MiR-132. It is developed by Cardior Pharmaceuticals to treat heart failure.[1][2][3]
References
- ↑ Batkai, Sandor; Genschel, Celina; Viereck, Janika; Rump, Steffen; Bär, Christian; Borchert, Tobias; Traxler, Denise; Riesenhuber, Martin et al. (7 January 2021). "CDR132L improves systolic and diastolic function in a large animal model of chronic heart failure". European Heart Journal 42 (2): 192–201. doi:10.1093/eurheartj/ehaa791.
- ↑ Taubel, Jorg; Hauke, Wilfried; Rump, Steffen; Viereck, Janika; Batkai, Sandor; Jenny, Poetzsch; Laura, Rode; Weigt, Henning et al. (3 September 2021). "Abstract 114: Safety And Efficacy Of CDR132L, A Novel Antisense Therapeutic Which Targets MicroRNA-132 In Heart Failure Patients". Circulation Research 129 (Suppl_1). doi:10.1161/res.129.suppl_1.114.
- ↑ Täubel, Jörg; Hauke, Wilfried; Rump, Steffen; Viereck, Janika; Batkai, Sandor; Poetzsch, Jenny; Rode, Laura; Weigt, Henning et al. (11 November 2020). "Novel antisense therapy targeting microRNA-132 in patients with heart failure: results of a first-in-human Phase 1b randomized, double-blind, placebo-controlled study". European Heart Journal 42 (2): 178–188. doi:10.1093/eurheartj/ehaa898. ISSN 0195-668X. PMC 7954267. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954267/.
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