Biology:BAZ1A

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Short description: Protein-coding gene in the species Homo sapiens

Bromodomain adjacent to zinc finger domain protein 1A is a protein that in humans is encoded by the BAZ1A gene.[1][2]

Structure

The protein encoded by this gene belongs to a family of proteins which includes BAZ1B, BAZ2A, and BAZ2B. All family members contain the following domains and structural motifs:[1]

Function

BAZ1A along with SMARCA5, POLE3, and CHRAC1 comprise the WCRF/CHRAC ATP-dependent chromatin-remodeling complex.[3][4]

The purified CHRAC complex can mobilize nucleosomes into a regularly spaced nucleosomal array, and the spacing activity is ATP-dependent.[4] Furthermore, the BAZ1A-SMARCA5 complex enables DNA replication through highly condensed regions of chromatin.[5]

Interactions

BAZ1A has been shown to interact with SMARCA5[3][4][6][7][8] and SATB1.[7]

References

  1. 1.0 1.1 "A novel family of bromodomain genes". Genomics 63 (1): 40–5. Apr 2000. doi:10.1006/geno.1999.6071. PMID 10662543. 
  2. "Entrez Gene: BAZ1A bromodomain adjacent to zinc finger domain, 1A". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11177. 
  3. 3.0 3.1 "A family of chromatin remodeling factors related to Williams syndrome transcription factor". Proc. Natl. Acad. Sci. U.S.A. 97 (3): 1038–43. February 2000. doi:10.1073/pnas.97.3.1038. PMID 10655480. Bibcode2000PNAS...97.1038B. 
  4. 4.0 4.1 4.2 "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". EMBO J. 19 (13): 3377–87. July 2000. doi:10.1093/emboj/19.13.3377. PMID 10880450. 
  5. "An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin". Nat. Genet. 32 (4): 627–32. December 2002. doi:10.1038/ng1046. PMID 12434153. 
  6. Bozhenok, Ludmila; Wade Paul A; Varga-Weisz Patrick (May 2002). "WSTF–ISWI chromatin remodeling complex targets heterochromatic replication foci". EMBO J. (England) 21 (9): 2231–41. doi:10.1093/emboj/21.9.2231. ISSN 0261-4189. PMID 11980720. 
  7. 7.0 7.1 Yasui, Dag; Miyano Masaru; Cai Shutao; Varga-Weisz Patrick; Kohwi-Shigematsu Terumi (Oct 2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature (England) 419 (6907): 641–5. doi:10.1038/nature01084. ISSN 0028-0836. PMID 12374985. Bibcode2002Natur.419..641Y. https://digital.library.unt.edu/ark:/67531/metadc733622/. 
  8. Hakimi, Mohamed-Ali; Bochar Daniel A; Schmiesing John A; Dong Yuanshu; Barak Orr G; Speicher David W; Yokomori Kyoko; Shiekhattar Ramin (Aug 2002). "A chromatin remodelling complex that loads cohesin onto human chromosomes". Nature (England) 418 (6901): 994–8. doi:10.1038/nature01024. ISSN 0028-0836. PMID 12198550. Bibcode2002Natur.418..994H.