Biology:4-chlorobenzoate dehalogenase

From HandWiki
Short description: Class of enzymes
4-chlorobenzoate dehalogenase
Identifiers
EC number3.8.1.6
CAS number94047-11-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a 4-chlorobenzoate dehalogenase (EC 3.8.1.6) is an enzyme that catalyzes the chemical reaction

4-chlorobenzoate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 4-hydroxybenzoate + chloride

Thus, the two substrates of this enzyme are 4-chlorobenzoate and H2O, whereas its two products are 4-hydroxybenzoate and chloride.

This enzyme belongs to the family of hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The systematic name of this enzyme class is 4-chlorobenzoate chlorohydrolase. This enzyme is also called halobenzoate dehalogenase.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1BVQ, 1JXZ, and 1NZY.

References

  • "Incorporation of [18O]water into 4-hydroxybenzoic acid in the reaction of 4-chlorobenzoate dehalogenase from pseudomonas spec. CBS 3". Biochemical and Biophysical Research Communications 124 (1): 178–82. October 1984. doi:10.1016/0006-291X(84)90933-1. PMID 6497878. 
  • "Enzymatic dehalogenation of certain brominated and chlorinated compounds". The Journal of Biological Chemistry 176 (2): 763–9. November 1948. PMID 18889931.